1 Title : Versican Promotes Tumor
نویسندگان
چکیده
Title: Versican Promotes Tumor Progression, Metastasis and Predicts Poor Prognosis in Renal 1 Carcinoma 2 Authors: Yozo Mitsui, Hiroaki Shiina, Taku Kato, Shigekatsu Maekawa, Yutaka Hashimoto, 3 Marisa Shiina, Mitsuho Imai-Sumida, Priyanka Kulkarni, Pritha Dasgupta, Ryan Kenji Wong, 4 Miho Hiraki, Naoko Arichi, Shinichiro Fukuhara, Soichiro Yamamura, Shahana Majid, Sharanjot 5 Saini, Guoren Deng, Rajvir Dahiya, Koichi Nakajima, Yuichiro Tanaka 6 Author’s Affiliation: Department of Urology, Shimane University Faculty of Medicine, Izumo 7 693-8501, Japan; Research service/Urology section, Veterans Affairs Medical Center and Department of 8 Urology, University of California, San Francisco, California, 94121; Department of Urology, Osaka 9 University Graduate School of Medicine, Suita 565-0871, Japan; Department of Urology, Toho 10 University Faculty of Medicine, Tokyo 143-8540, Japan 11 Running title: Impact of VCAN in Renal Cell Carcinoma 12
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Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling.
BACKGROUND Accumulation and infiltration of microglia/brain macrophages around and into glioma tissue promote tumor invasion and expansion. One tumor-promoting mechanism of microglia/brain macrophages is upregulation of membrane type 1 matrix metalloprotease (MT1-MMP), which promotes the degradation of extracellular matrix. MT1-MMP upregulation is induced by soluble factors released by glioma c...
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Interleukin-17A (IL-17A), a proinflammatory cytokine mainly produced by T helper 17 cells, exerts protumor or antitumor effects in different cancer entities. However, the exact role of IL-17A in carcinogenesis and progression of tongue squamous cell carcinoma (TSCC) remains unclear. Here, we found that the levels of IL-17A in serum and tumor samples were significantly increased in TSCC patients...
متن کاملVersican G3 Promotes Mouse Mammary Tumor Cell Growth, Migration, and Metastasis by Influencing EGF Receptor Signaling
Increased versican expression in breast tumors is predictive of relapse and has negative impact on survival rates. The C-terminal G3 domain of versican influences local and systemic tumor invasiveness in pre-clinical murine models. However, the mechanism(s) by which G3 influences breast tumor growth and metastasis is not well characterized. Here we evaluated the expression of versican in mouse ...
متن کامل5-Year Survival in Gastric Adenocarcinoma with Epithelial and Stromal Versican Expression
Background & Objective: Gastric cancer is the second most frequent cause of cancer death worldwide, despite differences in incidence around the world. The majority of gastric cancer cases concern gastric adenocarcinoma, which has a fairly high 5-year survival rate when coupled with early-stage diagnosis. Versican, a member of the aggregating chondroitin sulfate proteoglycans fa...
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Versican, a ubiquitous component of the extracellular matrix (ECM), accumulates both in tumor stroma and cancer cells and is highly regulated by various cytokines. The aberrant expression of versican and its isoforms is known to modulate cell proliferation, differentiation, and migration, all of which are features of the invasion and metastasis of cancer; versican is also known to favour the ho...
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